I find the driving position not as comfortable as , say, a Focus. I think it's to do with the slightly offset driving position. I feel fine while driving, but I do ache a bit when I get out. I do get a bit of a stiff right arm while driving though (I'm 6' 1").
Mind you, I have been driving other cars for a couple of months or so, so I suppose my body will have to get used to the 'Civic Style' again.
